klc kelly hose cover in stock

Flexible drilling rubber hoses play an important role in petroleum extraction. They should suffer high operating pressure, extreme operating temperature, abrasion and other inferior elements. Our special compounded synthetic rubber has been proven an effective and economical way to reject these problems. All our oilfield drill hoses are manufactured as API 7K or other related specifications.

Steel cable reinforcement loads most working pressure up to 15,000psi. The wires are usually zinc-plating or copper platting to improve steel wire resistant against rust and corrosion. Due to the thick reinforcement, the hoses should be handled or stored in correct way to avoid kicking or crushing. They will substantially decrease their rated operating pressure.

Rotary hose, Kelly hose, cement hose, mud hose, jumper hose and vibrator hose and choke & kill hoses are the most popular oilfield rubber hoses. They convey high-pressure drilling fluid from one place to another. Many end fittings are provided to satisfy different applications. Most end fittings are made according to API standards. Special order is also available.

Kelly hose is used to connect the standpipe to the swivel. It allows the drill string to be raised and lowered while the drill fluid is pumped through it. Kelly line usually contains two layers of plated steel cables to reach 5000 psi operating pressure. Inside tube is made of special NBR to improve abrasion and corrosion capability. Rubber cover is compatible with the ozone, sunlight and oils for a long time. It is supplied with multiple end fittings – API flanges, threads, butt-welded union and other as specified.

Nothing completes gardening when you do not have a hose. Then, why not upgrade it into something that makes it a complete package? Why not acquire a retractable hose that could make your gardening easier? Also, one would have no place in worrying about whether they are able to water every corner of their garden because of this high-standard hose.

Say goodbye to watering cans and in going back and forth just to get some water. If you got a retractable hose reel, you will have no fear of tripping over some cables or hose cords and you just can just navigate it with your hand easily because of its 180 to 360 swivel bracket that allows you to.

For durability, these hoses are one of a kind. Not only does it project convenience, but with its affordable price, one can ensure that it will function exceptionally well and is composed of durable materials that contribute to its longevity.

Getting the most reputable and durable hose reels - giraffe tools for your home might be one of your toughest decision because you always have to consider if the price is right for its features and functions. But what could you do is measure the cords first in the market and get a clear measurement of your garden so you will know how much feet of hose you will need

Aside from being convenient, Retractable Hose Reel is made up of an intensified polypropylene casing that can never fade away when it is exposed to sun. Simply, it is UV-Resistant. It also contains brass which depicts more durability than aluminium alloy material. Additionally, it has no memory and abrasion-resistant at all cost.

There is also this extremely convenient hose locker which helps you get your work done no matter how far you have gone in your garden. Simply, this hose locker allows you to lock and unlock the hose. In this way, you eliminate the hassle of pulling a specified hose length while watering your entire garden.

You can also get special retractable hose rell features such as Hose, (PVC), Bracket (PP) screws, plastics, Reel (PP), and metal (plugs) which was carefully analysed and assembled by experts to make sure that any pressure done by pulling the product does not affect its overall performance and quality.

Furthermore, this type of his is equipped with auto-rewind systems that avoids cable breakages when extended and utilised. From watering a huge area to the tricky and small portions of the garden, the 9-mode hose nozzle gives you the convenience like no other. Additional feature includes a 180-degree swivel bracket that allows you to navigate it in any motion you like.

It is a common misconception that when the hose is longer, you can reach any part of the garden. But the point is, a hose which focuses on its size can be less focused on its features. Sometimes, it can be pricey to which gets you in the side of the cliff.

Aside from this hindrance, longer hoses can give you certain challenges in pulling it off, storing it and draining it after use. What’s worse here is that it can also hinder the water pressure once it loops with vines or just maybe because of your wrong and excessive pulling.

But, with retractable hose reels, you can ensure that your gardening would be as smooth as ever. There is no wires, cables, or horse cords to trip over or to worry about. These type of hoses usually measures 3-5 feet yet it can be extended up to 155 feet depending on your needs.

Installation is rather convenient for you since retractable hoses has pre-installed 130 feet hybrid hose which can absolutely lock at any given length and ensure that every corner of the garden is covered. From the moment that you have installed the hose, it can automatically retracted as you pull it after usage. Also, for you to save some space, the 180-degree swivel bracket helps you in folding it back to the wall.

Rectratable hoses reel are perfect for those homeowners who wants to ensure that every corner of their garden would be hydrated on time. With this hose, your time being spent in watering would be lessened, allowing you to have more time in doing other things.

Although this type of hose reel can be costly but its features will give you the relaxation and convenience that you need. So, no need to think twice, go purchase one and experience the best!

The Weber Spirit II E-310 provides the unrivaled combination of top-notch grilling performance, a versatile three-burner design, durability, and a relatively affordable price. It excelled at every test, producing the best sear on our burgers of any grill, and equaling or outdoing the others in our tests involving barbecue chicken and whole roasted chickens. The Spirit II E-310’s overall compact size (helped by a fold-down side table) suits almost any patio or deck. And yet its grilling surface is big enough to cook a complete meal for a family or a dozen burgers for a party. With a thick cast-aluminum firebox, this model will last for years. (Weber’s warranty covers all parts for a full decade—among the best coverage in the industry.) For decades, the company has refined the Spirit’s design, too. This version includes an easily accessible externally mounted propane tank and an under-grill shelf. On top of all that, this grill is particularly easy to assemble, maintain, and use, and its finish comes in four colors (black, white, red, and blue).

The Spirit II E-310 also exhibited the most consistent heat across the entire cooking surface in the 2018 test, just as the original Spirit had done in 2017. Among the competition in our 2017 test, the Napoleon model in particular had noticeable cool spots toward the front of its grates. To a degree, all grills suffer from this problem, because the burners don’t extend all the way to the front of the firebox. But the Spirit II E-310 offered the most consistent heating across the entire grate surface. After 10 minutes, the burgers at the rear (the hottest part of the grill) were medium-well, and those at the front were medium-rare to medium (if your diners have various preferences, this difference might even be handy). On the Napoleon grill, meanwhile, some of the front burgers were nearly raw in the center, while the rear burgers were well-done.

During the low-and-slow grilling of the cut-up chicken, the Spirit II E-310 held almost perfectly steady at 375 °F, requiring almost no fiddling with the burner knobs—a quality it shared with the Genesis II. Both produced perfect barbecue chicken. By contrast, the Napoleon grill struggled to produce chicken with crisp, browned skin, and we soon discovered why: Its built-in thermometer was registering 50 degrees hotter than the actual temperature inside the grill. The result was flabby barbecue. The Broil King model had the opposite problem, running way too hot—as high as 450 °F, even with the burners on low. The result was charred chicken and burnt sauce.

The gas tank mounts externally (see the top photo in this section), instead of in a cabinet underneath the grill, as is typical (such as on the previous-generation Spirit). That makes it much easier to install a new tank and unhook an old one, because you’re not scrabbling around a small, dark enclosure to find the hoses and brackets. This design also allowed Weber to put a sturdy shelf under the grill—a handy place to store pans, bags of wood chips, a small cooler, and other stuff you may need while grilling. Plus, one of the side tables folds down, making the grill more compact for storage when it’s not in use (it’s 43 inches wide with the table down).

Several members of our staff have been using the Spirit II E-310 at home for the past three to four years, and they have reported that their grills have stayed in great shape and are still working well (you can read their notes just below). As a company, Weber constantly refines its designs, even on its classic charcoal kettle grill, which has been around for well over 60 years. And, again, Weber’s warranty covers all parts of the Spirit II E-310 for a full 10 years. So the company has a financial incentive to build it to last for years.

The Spirit II E-310 (and every grill) should come with a grill cover. This one doesn’t, nor did any grill in our test group, so you’ll need to buy one separately. Weber’s dedicated Spirit II cover costs about $80, and a well-regarded generic cover costs about $30 (both at the time of writing).

Wirecutter editor-in-chief Ben Frumin has been long-term testing the Spirit II E-310 since summer 2019. He says: “It replaced a years-old grill (a Kenmore, I believe) that was totally serviceable but kinda old and gross. I was immediately blown away by how much better our pick is. It was so easy to use. It heated up way faster than my old grill, cooked meat faster and more evenly, was easier to clean, and was just so clearly better overall. I use it to grill up burgers, hot dogs, salmon, chicken, mushrooms, Beyond Burgers, and a bunch of other stuff.” After nearly three years of using the grill (which was first acquired and tested by our team in 2018), Ben did have to replace the Flavorizer bars, or burner hoods. Unfortunately, he didn’t realize they were under warranty, so he did not contact Weber. “I also discovered recently that one of the three burners no longer ignites easily, which might mean it’s time for a good cleaning. For now, I just use a lighter to get it to catch.” Overall, however, Ben says the grill still works great.

We reviewed emerging immune strategies for multiple myeloma (MM) therapy excluding US FDA approved drugs. In relapsed refractory MM, isatuximab (anti-CD38) monotherapy achieved overall response (OR) of 24%. Other monoclonal antibodies that have shown efficacy in combination therapy include siltuximab (OR: 66%), indatuximab (OR: 78%), isatuximab (OR: 64.5%), pembrolizumab (OR: 60%), bevacizumab (OR: 70%), dacetuzumab (OR: 39%) and lorvotuzumab (OR: 56.4%). No OR was observed with monotherapy using BI-505, siltuximab, bevacizumab, AVE-1642, figitumumab, atacicept, milatuzumab, dacetuzumab, lucatumumab, IPH2101, lorvotuzumab, BT062 and nivolumab. We included seven clinical trials on chimeric antigen receptor (CAR) T cells. CAR T-cell targets include BCMA, CD19, KLC and CD138. A recent experience of CAR T-cell (B-cell maturation antigen) therapy in advanced MM has shown global response of 100%. The future of monoclonal antibodies and adoptive T cells for MM treatment seems promising.

Databases searched for English language studies included PubMed, Cochrane, EMBASE, Web of Science and Clinicaltrilas.gov. For clinicaltrials.gov, only completed studies or those actively recruiting were included. In addition to English language filter, only studies from last 10 years were included.

Kelly et al. (2016) Phase I/IIa47 (43 REP)Indatuximab ravtansine (ADC)CD1381–680–100 mg/m2NRIndatuximab + Dex + LenORR = 78%; PR = 33/47; mPFS 16.4 m[51]

Kelly et al. (2014) Phase I/IIa45 (36 REP)Indatuximab ravtansine (ADC)CD138380, 100, 120 mg/m2NRIndatuximab + Len + DexORR = 78%; sCR = 1; CR = 2; VGPR = 10; PR = 15; SD = 2[52]

PD-1 axis is involved in regulating T-cell activation and their apoptotic pathways. PD-1 is expressed on T-cell surface and its ligand PD-L1 on tumor cells. Their interaction inhibits T-cell proliferation. MoAb against PD-1/PD-L1 disinhibit T-cell proliferation and blocks immune escape by tumor cells [59]. We summarized results from three studies with anti-PD-1 MoAb (nivolumab, pembrolizumab and pidilizumab) in RRMM patients. Lesokhin et al. studied nivolumab in 27 RRMM patients with median three prior lines of therapy. Only one patient achieved OR [47]. Badros et al. studied pembrolizumab in combination with Pom and Dex in 48 RRMM patients with median three prior lines of therapy. Objective response was seen in 29/48 (60%) patients: 4 stringent CR (sCR), 9 VGPR and 16 PR. Median PFS of 17.4 months was seen [46]. Efebera et al. studied pidilizumab and lenalidomide in 12 RRMM patients with median two prior lines of therapy. One patient achieved PR and three achieved VGPR [48]. Kelly et al. showed pretreatment with oncolytic virus reolysin, through IFNγ/JAK/STAT axis, primarily regulated induction of PD-L1, induction of PD-L2 expression and improved anti-PD-L1 therapy in murine model (Table 2) [60].

CD138 is expressed on malignant cells in hematologic malignancies and solid tumors and is important for cell-to-cell adhesion as it acts as a co-receptor for MM growth factors [63]. In heavily pretreated patients, it is an important and reliable marker. Indatuximab ravtansine (IR, BT-062) is an immune conjugate of anti-CD138 chimerized MoAb and cytotoxic maytansinoid DM4. When BT062 binds to CD138, it is internalized and releases cytotoxic DM4, an antimicrotubule agent leading to death of MM cells. We summarized results from three studies on this ADC in RRMM patients. Heffner et al. studied IR as monotherapy in 29 RRMM patients, one patient achieved OR [53]. Kelly et al. studied this ADC in combination with lenalidomide and Dex in 64 RRMM patients with 3 median prior lines of therapy and reported an OR of 78% [52]. Kelly et al. in a head-to-head comparison of IR + lenalidomide and dexamethasone (Rd) versus IR + Pom and Dex found no significant difference in OR (78 vs 79%) (Table 2) [51].

MoAb-based combination regimens whose outcomes were not statistically significant include bevacizumab + Rd, bevacizumab + bortezomib, siltuximab + bortezomib and siltuximab + bortezomib, melphalan and prednisone. Role of anti-PD1 MoAb and indatuximab (anti-CD138) as monotherapy is questionable and needs further evaluation.

Chimeric antigen receptor (CAR) T-cells targeting B-cell maturation antigen (BCMA), CD19, KLC and CD138 have showed promising results in treatment of heavily pretreated and RRMM patients. CAR T cells acting on BCMA have been proved clinically more efficacious by Fan et al. with objective response rate of 100% (n = 19) but this efficacy is also associated with more severe cytokine release syndrome events. Most patients who received CAR T cells were heavily pretreated with ≥6 median prior lines of therapy. CAR BCMA T cells have also been associated with PRES and neurological deficits which are reversed with cyclophosphamide, steroids and anti-epileptics.

43. Rossi JF, Moreaux J, Hose D, et al. Atacicept in relapsed/refractory multiple myeloma or active Waldenström"s macroglobulinemia: a Phase I study. Br. J. Cancer.2009;101(7):1051–1058. PubMed]

51. Kelly KR, Siegel DS, Chanan-Khan AA, et al. Indatuximab ravtansine (BT062) in combination with low-dose dexamethasone and lenalidomide or pomalidomide: clinical activity in patients with relapsed/refractory multiple myeloma. Blood.2016;128(22):4486.

52. Kelly KR, Chanan-Khan A, Heffner LT, et al. Indatuximab ravtansine (BT062) in combination with lenalidomide and low-dose dexamethasone in patients with relapsed and/or refractory multiple myeloma: clinical activity in patients already exposed to lenalidomide and bortezomib. Blood.2014;124(21):4736.

TO ALL CREDITORS OF MUSTAPHA M. MANSARAY AND RITA S. SESAY, INCLUDING THOSE HOLDING LIENS BY JUDGMENT OR OTHERWISE ON THEIR REAL ESTATE, OR ANY PART THEREOF.

In pursuance of a decree of the Circuit Court of Jefferson County, West Virginia, made in a cause therein pending, to subject the real estate of Mustapha M. Mansaray and Rita S. Sesay to the payment of their debts, including those which are liens on such real estate, or any part of it, you are hereby required to present your claims to the undersigned for adjudication at the office of D. Frank Hill, III, located at  136 E. German Street, P.O. Box A, Shepherdstown, Jefferson County, West Virginia 25443-0600, on or before the 15th day of June, 2022; otherwise you may by law be excluded from all benefit of such real estate.

You are hereby notified that a Petition for Adoption has been filed with the Clerk of the Circuit Court of Jefferson County, West Virginia, and that you may serve upon Susan K. Paugh, Petitioner’s attorney, whose address is 314 West Stephen St., Martinsburg, WV, 25401, a responsive pleading to the Petition for Adoption on or before June 17, 2022. If you fail to do so default may be taken against you and your parental rights may be terminated.

The Issuing Office for the Bidding Documents is Corporation of Harpers Ferry – 1000 Washington Street, PO BOX 217 Harpers Ferry, WV 25425. Contact Person – Deb Kelly, dkelly@harpersferrywv.us. Prospective bidders may review solicitation and bid documents after registering for a vendor account at www.bidexpress.com. Fee is only required to submit bid. Bidders are required to obtain an Infotech Digital ID at www.bidexpress.com.

Implementation of P.L. 113-76, Consolidated Appropriations Act, 2014 applies an American Iron and Steel requirement to this project. All iron and steel products used in this project must be produced in the United States. The term “iron and steel products” means the following products made primarily of iron or steel: lined or unlined pipes and fittings, manhole covers and other municipal castings, hydrants, tanks, flanges, pipe clamps and restraints, valves, structural steel, reinforced precast concrete, and construction materials.